As SARS-COV2 reaches an endemic state, many high-income countries are trying to maintain low fatality rates through widespread vaccination. In contrast, low- and middle-income countries (LMICs) across Africa and Asia have made uneven progress towards managing the pandemic. In this essay we summarize our Annual Review of Economics article in which we look back at COVID-19’s impact on LMICs (Miguel and Mobarak 2022), and summarize an article recently published in Science (Mobarak et al. 2022) for which we assembled global experts representing economics, medicine, public health, and other related disciplines — many of them based in those LMICs — to discuss the strategies that need to be implemented to end the pandemic in LMICs.